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KMID : 1024520090180121391
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Journal of the Environmental Sciences
2009 Volume.18 No. 12 p.1391 ~ p.1398
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Effects of Ore Minerals on the Damages of Animal Cells
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Jeon Yu-Mi
Kim Jum-Ji
Lee Mi-Young
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Abstract
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In this study, we investigated the suppressive effects of ore minerals on the allergic cell damages and oxidative cell damages. The ore minerals significantly reduced the productions of tumor necrosis factor-alpha (TNF-α) and interleukin-4 (IL-4) in rat basophilic leukemia cells challenged with 2,4-dinitrophenol-bovine serum albumin (DNP-BSA). Lipoxygenase activity was also reduced by the ore minerals. Moreover, the ore minerals showed weak protective effects on the oxidative damage induced by hydrogen peroxide in pig kidney cells and retinal ganglion cells. Photohemolysis of erythrocytes in the presence of rose-bengal as a sensitizer was also inhibited by ore minerals. These results suggest that the ore minerals may be useful as the protectant for allergic and oxidative cell damages.
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KEYWORD
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Ore Minerals, Allergic cell damage, Oxidative cell damage
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